Due to their smaller chain length and lower molecular weight, LMWH has better activity against factor-Xa and inhibits thrombin to a lesser degree. Smaller heparin fragments cannot bind antithrombin and thrombin simultaneously. The primary difference between unfractionated heparin and enoxaparin is their relative inhibition of thrombin (factor-IIa) and factor-Xa. Enoxaparin is an indirect anticoagulant that binds and potentiates antithrombin III (serine protease inhibitor) through a specific pentasaccharide sequence to form a complex that irreversibly inactivates factor Xa. It has a quick onset of action when given in the intravenous form. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.Enoxaparin is low molecular weight heparin (LMWH) with a mean molecular weight of 4000 to 5000 Daltons. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. See the FDA's Safe Disposal of Medicines website ( ) for more information if you do not have access to a take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Instead, the best way to dispose of your medication is through a medicine take-back program. However, you should not flush this medication down the toilet. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Do not use the syringe if it leaks or if the fluid is dark or contains particles. Store the syringes at room temperature and away from excess heat and moisture (not in the bathroom). Keep this medication out of reach of children. Do not rub the site after you give the shot. Hold onto the skin the entire time you give the shot. Push the entire needle into the skin and then press down on the syringe plunger to inject the drug. Lie down and pinch a fold of skin between your finger and thumb.Do not push any air or drug out of the syringe before giving the shot unless your healthcare provider tells you to. Look at the syringe to be sure the drug is clear and colorless or pale yellow.Wash your hands and the area of skin where you will give the shot.To inject enoxaparin, follow these instructions: Keep syringes and needles out of reach of children. Your doctor, pharmacist, or health care provider will tell you how to dispose of used needles and syringes to avoid accidental injury. Do not use the syringe and needle more than one time. Each syringe has enough drug in it for one shot. If you have questions about where to give the shot, ask your healthcare provider. You must use a different area of the stomach each time you give the shot. Enoxaparin is usually injected in the stomach area. Your healthcare provider will teach you how to give yourself the shot or arrangements will be made for someone else to give you the shot. Do not stop taking enoxaparin without talking to your doctor. Do not inject more or less of it or inject it more often than prescribed by your doctor.Ĭontinue to use enoxaparin even if you feel well. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. You will probably begin using the drug while you are in the hospital and then use it for a total of 10 to 14 days. Enoxaparin comes as an injection in a syringe to be injected just under the skin (subcutaneously) but not into your muscle.
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